17-OH-progesterone (17-hydroxyprogesterone, 17-OGG, 17-oh-progesterone) yog cov tshuaj hormones; ib hom ntawm "semi-finished product", los ntawm ntau yam tshuaj hormone (cortisol, estradiol, testosterone) yog tsim nyob rau hauv txoj kev ntawm metabolic hloov.
Qhov ua rau muaj 17-OH-progesterone ntxiv
Yog vim li cas thiaj li tau nce qib ntawm 17-oh-progesterone ntau dua nyob rau hauv qog qog qog los yog zes qe menyuam. Congenital adrenal cortex dysfunction (PDCN) yog qhov ntau tshaj plaws ua rau muaj kev nce ntxiv. Adrenal kawg yog txuam nrog ib deficiency los yog tsis muaj ib qho 21-hydroxylase enzyme, uas, nrog 17-OH-progesterone, koom tes hauv cov khoom siv cortisol. Lub enzyme tsis tuaj yeem los yog tam sim no me me, tam sim no raws li tus precursor ntawm cov tshuaj hormones 17-OH-progesterone yog nquag ua li qhov dhau ntawm qhov ntau.
Muaj ob hom VDKN: classical thiab non-classical. Hom VDKN yog txiav txim siab rau thawj hnub / hli ntawm tus me nyuam lub neej los ntawm sab nraud cov kev tshwm sim ntawm kev tsis txaus siab hermaphroditism. Yog tias tus poj niam muaj teeb meem ntawm kev xav thiab kev qoj ib ce (gestation), nws muaj peev xwm ua tau rau cov neeg tsis paub qab hau (VDKN), raws li txoj cai, nws tsuas ua tau rau tus neeg hluas xwb (tiv thaiv cov keeb kwm: hirsutism, pob txuv, pob txuv, ua tsis raws cai).
Tsis tas li ntawd, kev kuaj ntshav rau kev txiav txim siab txog qib 17-OH-progesterone tuaj yeem pom tus tshaj qhov ntau yog tias:
- polycystic syndrome syndrome (PCOS);
- androgen-ua cov qog ntawm qe menyuam lossis qog lub caj dab;
- mob los yog Syndrome ntawm Itenko-Cushing;
- hypothalamic syndrome;
- hyperprolactinemia ;
- thiab lwm yam kab mob.
Tus cai tswj hwm ntawm 17-OH-progesterone
Cov kev cai ntawm cov tshuaj hormones, tshwj xeeb tshaj yog lawv cov neeg ua ntej 17-OH-progesterone, kuj yuav txawv hauv cov chaw kuaj kab mob sib txawv. Hauv kev ntsuam xyuas yuav tsum tau ua raws li cov kev qhia ntawm ib qho kev kuaj, lawv feem ntau tau pom nyob rau hauv cov txiaj ntsim ntawm kev ntsuam xyuas.
Cov kws kho mob cov kws kho mob yuav ntseeg tias qib 17-OH-progesterone hauv tus poj niam uas tsis muaj menyuam muaj peev xwm yuav tsum tsis txhob muaj kev kho mob thiab nws yog ib qho txawv ntawm cov cai. Qhov kev txwv ntawm qhov nce no yog 5 nmol / L = 150 ng / dl = 1.5 ng / l.
Cov poj niam cev xeeb tub tsis tuaj ntsuam xyuas ntshav rau 17-OH-progesterone, thaum lub sijhawm cev xeeb tub, theem 17-GPG nce, qhov tseeb yog qhov muaj sia muaj sia. Thiab yog li ntawd nws yog qhov tseem ceeb rau kev kho mob ntawm qib 17-OH-progesterone thaum lub sijhawm cev xeeb tub. Cov kev zam tsuas yog cov xwm txheej ntawm VDKN classical.
Yuav ua li cas kom txo tau 17-OH-progesterone?
Yog tias, raws li cov txiaj ntsig ntawm kev sim, qib 17-OH-progesterone nce, nws tseem ceeb heev kom nkag siab txog qhov ua txhaum cai ua ntej pib kev kho mob. "Qhov muag tsis pom kev" kev kho, ua rau coob tus kws kho mob, ua rau cov laus siv cov kev kho mob, tsis daws qhov teeb meem, tiam sis feem ntau ua rau nws mob.
Yog li, yuav ua li cas kom txo tau qib 17-OH-progesterone? Txawm hais tias muaj qhov cuam tshuam los ntawm kev nce, ib tug poj niam yog tus kws kho mob kom siv ntev COC - kev siv tshuaj tiv thaiv kabmob (Jess, Tomin, Diana-3 lossis lwm tus). Yog li, yog tias ib tug poj niam raug kuaj nrog PCOS, nrog rau kev ua haujlwm ntawm cov qog ntawm qog ntawm ib COC-kev kho ua ntej cev xeeb tub, feem ntau yog txaus.
Yog hais tias qhov ua rau muaj qib 17-OCG yog ib qho VDKN nonclassical, ib qho kev xeem kev soj ntsuam ntawm endocrinologist thiab genetics tseem ceeb,
Txaus siab rau 17-OH-progesterone hauv feem ntau ntawm cov mob yog kev mob nyaum ntxiv. Dexamethasone, prednisolone los yog lwm yam kab mob glucocorticosteroids yuav tsum tau txhaj nkaus xwb thaum muaj qhov tseeb ntawm cov PDCA uas tau muab pov thawj thiab tsuas yog qhia tias qhov kev xeeb tub tsis muaj ntau tshaj li 1 xyoos, thiab tag nrho lwm cov ua tau ua rau mob ntxiv lawm.