Verapamil yog ib qho tshuaj uas tau qhia rau cov tshuaj calcium channel, yog tias tsim nyog. Cov tshuaj Verapamil muaj ntau qhov kev siv rau kev siv. Nrog kev pab ntawm nws, koj tuaj yeem ua tus mob prophylaxis ntawm angina tawm tsam, thiab Prinzmetal angina pectoris thiab.
Action ntawm yeeb tshuaj Verapamil
Lub ntsiab ntawm cov tshuaj pharmacological ntawm cov tshuaj no yog vim nws muaj peev xwm zoo heev tsis pub calcium ions nkag mus rau hauv lub hlwb cov leeg ntawm cov hlab ntsha thiab hauv cardiomyocytes. Tus cwj pwm ntawm cov tshuaj ua rau txo tau qhov kev xav tau rau myocardium hauv O2 (oxygen), txo cov mob myocardial contractility thiab txo lub plawv dhia.
Tsis tas li ntawd, verapamil muaj peev xwm nthuav cov tsos mob ntawm kev mob plab, li no, nws ua rau cov ntshav muaj zog tuaj. Txo cov tone ntawm cov nqaij ntshiv ntawm peripheral, Verapamil muaj ib qho kev siv tshuaj tua kabmob (antihypertensive effect). Nrog supraventricular arrhythmias, nws ua rau ib qho kev siv tshuaj antiarrhythmic, coj lub plawv dhia rov qab rau qub.
Verapamil yog dab tsi?
Cov tshuaj no yog qhia rau:
- angina pectoris;
- supranventicular, ciliary thiab sinus tachycardia ;
- arterial hypertension.
Cov kev qhia rau kev siv cov verapamil yog hypertensive teebmeem, qib siab tawg hauv lub voj voog me me ntawm ntshav.
Kuj tsim rau kev kho thiab kev tiv thaiv ntawm ntau supraventricular arrhythmias:
- extrasstole;
- paroxysmal tachycardias;
- flutter thiab atrial fibrillation.
Tom qab noj tshuaj, cov tshuaj yog absorbed los ntawm 90%, thiab nws cov bioavailability yog 20-35% thaum thawj zaug dhau los ntawm nplooj siab. Nrog rau kev nkag tau mus ntev thiab kev txhaj tshuaj loj, qhov ntsuas no nce.
Kev siv thiab qhov contraindications ntawm cov tshuaj Verapamil
Tus kws kho mob yuav tsum sau txoj kev tswj hwm thiab tshuaj noj ib leeg zuj zus. Raws li txoj cai, rau cov neeg laus, thawj koob tshuaj yog los ntawm plaub caug yim caum milligrams peb zaug ib hnub. Qhov ntau tshaj plaws txhua hnub koob tshuaj yog 480 mg.
Sib npaug ntawm daim ntawv thov yog peb mus rau plaub zaug hauv ib hnub. Noj tshuaj thaum noj mov lossis tom qab noj mov, tsis tas yuav tsis nco qab haus dej me me.
Contraindicated nyob rau hauv kev siv ntawm Verapamil rau cov neeg uas muaj:
- cardiogenic poob siab;
- hais tau bradycardia;
- arterial hypotension;
- Syndrome ntawm kev qaug zog ntawm qhov ntswg;
- AV blockade ntawm qib 2-3;
- kev mob plawv tsis ua hauj lwm ntawm lub sij hawm 2-3th;
- Wolff-Parkinson-Dawb Syndrome;
- mob plawv tsis ua haujlwm;
- hypersensitivity rau cov nyob tus yeees ntawm lub tshuaj.
Cov tshuaj muaj cov teebmeem uas cuam tshuam rau lub cev lub cev:
1. Lub plawv hlav plawv:
- txo cov ntshav siab;
- bradycardia;
- hnyav thiab kev loj hlob ntawm lub plawv tsis ua hauj lwm;
- arrhythmia;
- cev qhuav dej.
2. Peripheral lub paj hlwb thiab CNS:
- mob taub hau;
- kiv taub hau;
- tsaus muag;
- ntxhov siab vim;
- nce qaug zog;
- kev nyuaj siab;
- nkees nkees;
- retardation;
- trembling ntawm cov ntiv tes;
- ataxia;
- shuffling kev sib tw;
- nyuaj nqos.
3. Lub plab zom:
- cem quav;
- xeev siab;
- los ntshav thiab o ntawm cov pos hniav;
- nce qab los noj mov.
4. Cov kev tsis haum tshuaj:
- khaus;
- pob;
- erythema;
- hyperemia ntawm daim tawv nqaij ntawm lub ntsej muag.
Qhov tsis zoo ntawm kev noj cov tshuaj no yog:
- phaus nce;
- kev tsis pom kev tsis pom kev;
- pulmonary edema;
- mob caj dab;
- peripheral edema.
Verapamil nrog huab ceev ceeb toom yog tus kws kho mob yog tias tus neeg mob:
- impaired daim siab ua haujlwm;
- muaj ib qho mob khees-xaws rau tus kabmob tsocai (myocardial infarction).
Nws kuj tsis tsim nyog los noj tshuaj los ntawm cov neeg koom nrog cov kev ua phem uas yuav ua teeb meem, uas yuav tsum tau muaj kev mloog ntau dua thiab ua rau muaj kev ntxhov siab, cov poj niam cev xeeb tub thiab cov poj niam uas nyuam qhuav yug me nyuam.