Cov chav kawm ntawm tib neeg cov kab mob, li kev kho mob autoimmune, yog txuam nrog impaired immune system functions thiab pathological zus ntawm autoimmune antibodies uas ua txhaum tawm tsam lub cev nqaij daim tawv thiab ua rau lawv cov kev hloov pauv lossis kev puas tsuaj. Cov kab mob no tuaj yeem ua rau lub nruab nrog cev thiab cov kab mob, nrog rau lub siab. Yog li, cov poj niam, tshwj xeeb tshaj yog thaum muaj hnub nyoog 40-50 xyoos, thawj tus kabmob qog siab ntawm daim siab yuav tsim tau, thiab ntau zaus tus neeg muaj tus kab mob ntawm tus kabmob (xws li cov viv ncaus, niam thiab tus ntxhais, thiab lwmyam).
Ua rau thiab theem ntawm thawj koob tshuaj tiv thaiv kev ua npuas
Thaum lub sijhawm no, nws tsis paub meej tias txoj kev txhim kho kev ua haujlwm rau kev loj hlob ntawm thawj tus biliary cirrhosis, ntawm qhov kev tshawb nrhiav qhov teeb meem thiab kev sib tham yog nyob rau hauv txoj kev. Ntawm cov kev xav txog qhov ua rau pathology yog cov hauv qab no:
- kis kab mob kis (kab mob viral thiab kab mob) (tsis ntev los no cov lus hais txog kab mob ntawm tus kab mob yog nug heev);
- hormonal ntshawv siab;
- caj ces yam;
- cuam tshuam rau lub cev ntawm cov tshuaj;
- lwm yam kab mob autoimmune (rheumatoid mob caj dab, Raynaud tus kab mob, Sjogren's syndrome, autoimmune thyroiditis, scleroderma, tubular renal acidosis, thiab lwm yam).
Muaj plaub theem nyob rau hauv kev loj hlob ntawm tus kab mob:
- Thaum pib thawj, tshwm sim los ntawm qhov kev txiav txim siab txog kev kho mob autoimmune, ib qho inflammatory inflammation ntawm intrahepatic bile ducts tshwm sim, hem stagnation yog cai.
- Tom qab ntawd muaj ib tug txo nyob rau hauv lub xov tooj ntawm bile bile, blockade ntawm excretion ntawm bile thiab nws nkag mus rau hauv cov ntshav.
- Lub phais lub vev xaib ntawm daim siab yog hloov nrog caws pliav nqaij, cov cim ntawm kev mob thiab cov necrotic phenomena nyob hauv parenchyma.
- Qis me me- thiab coarse-nodular cirrhosis nrog rau cov cim ntawm peripheral thiab central cholestasis.
Cov tsos mob ntawm thawj koob cirrhosis
Thawj tshwm sim ntawm pathology, uas cov neeg mob feem ntau yws, yog:
- tsis muaj zog zuj zus, qaug zog, tsaug zog nce, txo kev ua ub no thiab ua tsis taus hauj lwm;
- tawv nqaij khaus khaus (feem ntau yog hais, zuj zus thaum hmo ntuj, thiab tom qab siv dej da, kov cov khoom uas muaj ntaub qhwv);
- thickening ntawm daim tawv nqaij, ntxiv dag zog rau daim tawv nqaij;
- icterus ntawm daim tawv nqaij, mucous membranes, sclera;
- qhuav qhov muag ;
- tsis xis nyob, rhiab hauv txoj cai hypochondrium.
Tsis tas li ntawd, cov neeg mob feem ntau cuam tshuam los ntawm me ntsis nce hauv lub cev kub, mob taub hau, tsis qab los noj mov, hnyav, nyuab siab. Hauv qee tus neeg mob, thawj koob tshuaj tiv thaiv kabmob ua npau suav nyob rau theem pib ntawm cov nyiaj them poob haujlwm yog zoo li asymptomatic.
Tom qab ntawd cov tsos mob nram qab no ntxiv rau cov tsos mob li nram no:
- Vascular sprouts ntawm daim tawv nqaij;
- liab liab ntawm lub ntsej muag, taw thiab xib teg;
- deformation ntawm cov ntsia hlau ("saib iav"), cov tsos mob ntawm cov xim dawb transverse rau lawv;
- thickening ntawm ntsia phalanges.
Vim hais tias kev cuam tshuam ntawm kev nqus ntawm cov vitamins thiab lwm yam kev muab tshuaj, osteoporosis, steatorrhea, hypothyroidism, varicose leeg ntawm hemorrhoid thiab esophageal leeg, ascites, nce ntshav thiab lwm cov teeb meem kuj tau.
Kev kuaj ntawm thawj koob biliary cirrhosis
Lub sijhawm ntawm qhov kev kuaj mob no yog nyob ntawm kev ntsuam xyuas kuaj mob:
- kev ntsuas ntshav;
- biochemical ntshav kuaj ;
- coagulogram;
- tshuaj ntsuam mob hepatic;
- lipidogram;
- kev ntsuam xyuas ntawm zis.
Paub meej tias qhov kev kuaj mob yog ua tau los ntawm lub siab ua nqaij daim tawv, uas yog ua tiav hauv kev tswj ultrasound.
Kev kho mob thawj koob cirrhosis thawj zaug
Kev kho tshwj xeeb ntawm tus kab mob no tsis muaj nyob, tsuas yog txoj kev uas txo cov kev mob tshwm sim, qhov kev txwv ntawm kev mob ntswg, tiv thaiv kev loj hlob ntawm cov teeb meem loj. Feem ntau, cov no yog cov khoom noj tshuaj nrog rau lub sij hawm ntawm kev siv tshuaj tiv thaiv, glucocorticosteroids, cholagogues, hepatoprotectors, antihistamines, etc. Qhov kev siv lub cev muaj tus kab mob kuj yog kev noj haus tshwj xeeb. Thaum mob hnyav, cov kev phais mob yog ua tiav ntawm txoj kev ua rau lub siab hloov.