Neurological kab mob ntawm migraine , uas yog tsiag ntawv los ntawm bouts ntawm mob siab heev thiab mob mob taub hau, yog heev niaj hnub no. Hauv kev kho mob ntawm migraine, kev npaj ntawm ntau pawg, thiab cov tshuaj nws tus kheej yog tsom rau ob qho tib si ntes cov kabmob migraine thiab tiv thaiv lawv (kev tiv thaiv). Kev xaiv cov tshuaj tiv thaiv cov tshuaj tiv thaiv no yog siv rau cov neeg mob ib leeg zuj zus, suav nyiaj rau kev xav, kev xav ntawm tus kheej, kev muaj cov kab mob sib kis, qhov mob, thiab lwm yam.
Ib qho tshuaj zoo tshaj plaws rau kev tshem cov tsos mob ntawm tus kabmob migraine yog cov kev npaj rau pawg neeg ntawm cov neeg yos hav zoov. Triptans yog cov yeeb yaj kiab uas tsis yog siv los pab daws qhov mob lwm tus thiab lwm cov mob migraine, tab sis kuj txo qis ntawm qaug dab peg.
Mechanism ntawm kev txiav txim ntawm triptans
Triptans yog cov tshuaj rau migraine, uas raug nquahu rau cov neeg mob uas muaj mob hnyav (sib cem), thiab nrog rau qhov qhia tau tias muaj kev tsis zoo. Triptans yog cov kab mob ntawm serotonin, tus neeg kho kom haum xeeb ntawm lub paj hlwb.
Lub caij nyoog thiab ua tiav mechanism ntawm kev txiav txim ntawm cov tshuaj ntawm no pab pawg neeg tsis tau txaus kawm tshawb kom deb li deb. Nws xav tias cov tshuaj no tiv thaiv migraine tawm tsam, muaj cov teebmeem nram qab no rau lub cev trigeminovascular system (neurons ntawm trigeminal nerve core thiab cerebral vessels), uas yog ib qho tseem ceeb hauv lub "tua" ntawm qhov kev raug mob):
- inhibition ntawm trigeminal hlab hlwb (cov nyhuv nyhuv neuroinhibitory);
- txhuam cov kab mob cerebrospinal thiab cov hlab ntsha ntawm lub paj hlwb thiab qeeb ntawm cov ntshav khiav hauv lawv (vasoconstrictor action).
Nws yuav tsum tau muab sau tseg tias qhov chaw mus txawv tebchaws tsis cuam tshuam lwm cov hlab ntsha ntawm tib neeg lub cev.
Hom ntawm triptans
Thawj zaug mus, uas pib siv rau migraine, yog sumatriptan. Kev siv lub cuab yeej no, nws txoj kev tshawb nrhiav, kev soj ntsuam tau raug tso cai los txhim kho cov teebmeem ntawm cov menyuam yaus thiab tsim cov tshuaj yeeb-tshuaj tshiab. Txog hnub tim, cov tshuaj siv tau zoo tshaj plaws thiab dav siv los ntawm cov pab pawg ntawm cov tuaj yeem yog:
- Naratriptan;
- Frovatriptan;
- Eletriptan;
- Risotriptan;
- Zolmitriptan;
- Almotriptan thiab lwm tus.
Raws li txoj cai, cov tuaj yos hav zoov muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj rau kev tswj hwm qhov ncauj. Txawm li cas los xij, tseem muaj kev npaj rau cov pab pawg neeg no rau cov tshuaj tua kab mob (tshuaj tsuag) thiab cov tawv nqaij (cov hnoos qeev), nrog rau cov thaij (triptans) hauv daim nplaub tshev.
Ntaus ntawm triptans
Yuav tsum tau noj cov tshuaj tiv thaiv tam sim ntawd tom qab qhov pib ntawm cov tsos mob ntawm thawj zaug ntawm qhov mob migraine. Cov ntsiav tshuaj tsis tuaj yeem tau txais, lawv yuav tsum tau muab ntxuav nrog dej kom ntau. Raws li txoj cai, ib lub ntsiav tshuaj muaj zog txaus kom nres. Yog tias qhov mob tsis tuaj yeem tso, tom qab ntsiav tshuaj tom qab 2 xuab moos. Ntxiv dag zog rau kev sib koom tes ntawm kev siv cov tshuaj ntawm cov chav kawm no nrog cov tshuaj non-steroidal anti-inflammatory (ntawm kev pom zoo ntawm tus kws kho mob).
Tsis txhob siv thawm lub sijhawm thaum lub migraine aura . Nrog rau lub xeev siab thiab ntuav, qhov quav, qhov ntu nruab nrab ntawm txoj kev khiav haujlwm yog qhov zoo dua. Tryptans tsis tuaj yeem noj ntau zaus tshaj 2 zaug ntawm ib lub lim tiam. Koj tuaj yeem tsis muab lawv cov tshuaj siv nrog tshuaj tua kab mob, tshuaj tua kab mob los yog tshuaj tua kab mob antidepressants.
Yuav ua li cas txaus ntshai yog triptans?
Cov kev tshawb fawb soj ntsuam qhia tias kev ua siab ntev ntawm kev sib tw rau cov neeg mob txawv.
Triptans muaj kev tsis sib haum xeeb xws li:
- arterial hypertension;
- mob ntev ntawm kab mob cerebral;
- lub plawv tsis ua haujlwm;
- ischemic plawv;
- mob ntsws loj thiab mob tsis zoo;
- cev xeeb tub thiab lactation.